Industry News

With the development of biotechnology, the importance of cell culture in fields such as medicine, food, and biomaterials has become increasingly prominent. Meanwhile, bioreactors used for cell culture are also constantly evolving to meet the growth requirements of various types of cells. Although bioreactors and traditional microbial fermenters may seem similar in appearance and structure, there are significant differences between them in core principles, operating conditions, application fields, control parameters, and design details. This article will delve deeply into the differences between bioreactors used in cell culture and traditional microbial fermenters from multiple dimensions.

With the rapid development of synthetic biology, metabolic engineering and systems biology, microbial fermentation technology has shown great potential in fields such as food, medicine, energy, chemical engineering and environmental protection. From laboratory culture flasks to industrial-scale ten-thousand-ton fermentation tanks, the industrialization path of microbial fermentation is not only fraught with technical barriers but also holds tremendous commercial value. In this process, as one of the core equipment, the manufacturing enterprises of fermentation tanks are also facing unprecedented opportunities and challenges.

In modern biological fermentation processes, the fermentation tank, as the core equipment, its hygiene condition directly affects the quality of the product and production safety. To ensure that there are no microbial residues and no cross-contamination on the surface of the equipment, the automated in-situ cleaning (CIP) technology is widely used in fermentation systems. This article will systematically introduce the process flow, key parameter control and verification methods of CIP cleaning in fermentation tanks, aiming to provide standardized and scientific operation guidelines for the biopharmaceutical, food, brewing and other industries.

Biological fermentation is an industrial biological process widely applied in the fields of pharmaceuticals, food, environmental protection, energy, etc. During the fermentation process, the metabolism of microorganisms releases a large amount of heat. Especially in industrial fermentation tanks with high density, high aeration and high-speed stirring, the accumulation of heat may lead to an increase in temperature, thereby inhibiting the activity of microorganisms or the synthesis of products. Therefore, controlling the fermentation temperature has become a key link to ensure the stability of the fermentation process and high product quality.